The hCG level after the injection rotted 1500. Pregnyl is the official * instruction for use. Instructions for use and scheme of use

Unfortunately, more and more modern women are faced with difficulties in conceiving a child. The desired pregnancy may, one of which may be a lack of female sex hormones - estrogen and progesterone, due to which the egg does not mature and ovulation does not occur. In this case, a woman at the planning stage of pregnancy (as well as to preserve it during gestation), together with supportive therapy, may be prescribed hormonal drugs, for example, Pregnyl.

What is Pregnyl?

Pregnyl is a preparation of the human chorionic gonadotropin hormone. It can be assigned to both women and men, and even children, but with completely different purposes. Most often, Pregnyl for women is prescribed when planning a pregnancy as an auxiliary method before, to stimulate the ovaries or to support the luteal phase of the menstrual cycle.

The course of treatment and dosages are determined by the doctor in each case individually.

Pregnyl is injected intramuscularly. Depending on the indications, the hormone can be administered once or several times at intervals of several days.

How long does Pregnil take off?

The maximum concentration of the hormone hCG in the blood plasma after the injection of Pregnil in women occurs after about 20 hours. The excess of the drug is excreted in the urine for several days after the injection. The elimination period of Pregnil depends on the dose: the larger it is, the longer it is. An earlier pregnancy test after Pregnil may show.

When can a pregnancy test be done after Pregnil?

Of course, every woman is eager to find out the result of this cycle and quickly find out if the long-awaited pregnancy has come. If you conduct a pregnancy test after Pregnil, then it should be borne in mind that, according to the instructions for the drug, it can be considered reliable when it is carried out on the 10th day and later after receiving the last injection of Pregnil. However, doctors recommend that the test be carried out no earlier than 2 weeks after ovulation or embryo replanting.

It should be noted that an early pregnancy test can be both false positive and false negative! So no premature conclusions, girls!

For reliability, you need to track hCG level in dynamics. Best of all with the help of a laboratory blood test, but for more later dates after ovulation, several pregnancy tests can be done several days apart.

The final "diagnosis" can only be made by a doctor. No rest in peace to you!

Especially for Elena Kichak

In the process of in vitro fertilization, the transfer of the embryo is the final stage, after which the doctor in mandatory will prescribe funds to support the luteal phase. These drugs help improve implantation. This includes HCG drugs, progesterone. When the transference has taken place, the patient goes through a difficult and stressful period. It remains to be seen whether the pregnancy will come or not. Therefore, many patients are interested in why rot is prescribed after embryo transfer.

Embryo transfer

The onset of pregnancy is determined using a certain analysis after two weeks. According to the analysis, the hCG hormone is measured. It is synthesized only by the cells of the embryo. Hence, it is very long days in the life of a woman who wants to get pregnant.

After the embryo implantation process, experts advise against taking a hot shower or bath, not performing heavy physical activity, and also giving up sexual intercourse for now. But the very next day the girl can go about her activities, enter the usual mode of life. But some women don't get out of bed for two weeks until they get tested. They get up to eat and go to the toilet.

Perhaps this is necessary so that when pregnancy does not occur, do not reproach yourself for anything and be calm that everything has been done. But it is worth remembering that standard activity does not affect the likelihood of pregnancy. After the transfer of the embryos, the doctor prescribes hormonal drugs.

Naturally, the cycle of menstruation becomes longer. The drug is excreted from the body individually for each patient. This process is influenced by metabolic processes, weight. Basically, this happens for about five days.

Pregnyl after embryo transfer has an effect of increased work of the corpus luteum.

Doctors say that with the help of rot, the ovaries' own functions are activated and maintained. The dosage is prescribed for each patient individually. The doctor sets the dose based on how active the ovaries are, what hormone levels are, and how the stimulation is done.

Application

In the course of treatment, the time of administration of hCG is considered a serious moment, respectively, the drug should be administered at the exact time that is calculated. Wash and dry your hands well. Initially, prepare a syringe, cotton balls with alcohol and a drug.

The ampoule with a dry composition is pulled out of the box, the plastic covers that protect it are removed. Each ampoule is separately processed with a cotton pad moistened with alcohol.

Insert the needle from the syringe into the very center of the rubber cap of the jar where the solvent is located. Turn the ampoule over. Draw 3 ml of solvent into a syringe. Then remove air from the syringe, perform an intramuscular injection. After embryo transfer, Pregnyl or Horagon is prescribed to prick.

Why Pregnyl is pricked after embryo transfer:

• 3⁄4 Induce ovulation;
• 3⁄4 The egg matures in the artificial insemination program;
• 3⁄4 After ovulation has occurred, the corpus luteum appears. The drug helps the ovaries to secrete progesterone.

Experts say that rot in support increases the chance of a successful pregnancy.

Horagon and rot

How long does it take to ovulate after taking rot? This drug not only initiates ovulation, but also controls it. Therefore, ovulation should take place no earlier than 35 hours. If this happens before, then such cases are an exception. So about half of the processes of artificial insemination would not give results. Thus, pregnyl is applied 35 hours before the puncture. Some women claim that the level of hCG decreases after rotting 1500, and the test begins to give positive results.

How much does the rotted 1500 go? This is individual, perhaps some patients drink a large number of liquids. But basically this process lasts about twelve days.

In a situation where the follicle has grown, but does not rupture, choragon is used. The active substance is human hCG, according to which the onset of pregnancy is determined.

How to breed a choragon? You can dilute with one ampoule. Pour the solvent into the dry substance, dilute, draw into a syringe. Haragon 1500 after embryo transfer is prescribed to deceive the body. It seems to the body that it has become pregnant, so it works for the embryo. HCG in the blood is produced when a woman is pregnant.

Thus, many are interested in what is better rot or choragon? According to opinions, the drugs do not differ much from each other. In some clinics, only pregnil is prescribed, while in others, only choragon is prescribed. If you pay attention to the reviews, then the patients do not really see the difference. What is Ovitrel or Rotten better? The drugs are prescribed individually. The difference is that Ovitrel is injected into the abdomen. Each patient tolerates the drug differently.

Tradename: Pregnyl ®

International non-proprietary name:

Dosage form:

Composition of the preparation:
Active substance:
chorionic gonadotropin 1500 or 5000 international units (ME) in 1 ampoule.
Excipients:
carmellose sodium, mannitol, sodium hydrogen phosphate, sodium dihydrogen phosphate.

Description
Lyophilisate or lyophilized powder white.
Solvent: colorless, transparent solution.

Pharmacotherapeutic group:

ATX Code: G03GA01

Pharmacological properties
Pharmacodynamics
Pregnyl ® contains hCG (human chorionic gonadotropin). This hormone has a biological activity similar to that of LH (luteinizing hormone). LH is indispensable for normal growth and the maturation of female and male gametes and for the formation of sex hormones.
Among women:
Pregnyl® is used as a mid-cycle substitute for endogenous LH to induce the final phase of follicular maturation leading to ovulation. Pregnyl ® is also used as a substitute for endogenous LH during the luteal phase.
In men and boys:
Pregnyl ® is used to stimulate Leydig cells to accelerate the formation of testosterone.

Pharmacokinetics
The maximum concentration of hCG in blood plasma after a single intramuscular or subcutaneous injection of hCG is achieved after 6-16 hours in men and approximately 20 hours in women. Despite the fact that there is a high individual variability, sex differences in the rate of absorption of the drug after a single intramuscular injection are most likely associated with a greater thickness of subcutaneous fat in women. Approximately 80% of hCG is metabolized in the kidneys. Found that a single intramuscular or subcutaneous hCG injection are bioequivalent in terms of duration of absorption and an apparent half-life of approximately 33 hours. Given the recommended dosage regimens and elimination half-life, cumulation of the drug is not expected.

Indications
Among women:

Post date: 15.11.2015 14:15

Natalia

Good afternoon, Gary Zelimkhanovich !! Excuse us women for repetitive questions, well, we are very impatient! Please answer 2.10 Pregnil 10000 was injected! Today at 14.10 I did a test, since the last day of taking duphaston and I'm afraid to cancel, and since the day off to donate blood for hCG is not possible, and for the same reason I can not ask a doctor! So the test bb with a sensitivity of 10 showed a second, but weak strip, Eviko with a sensitivity of 15 is silent! What should I do? Cancel Duphaston? Could this be my HCG or is it the remnants of the injection? Thanks a lot in advance for your reply!

Post date: 15.11.2015 14:18

Natalia

I apologize, I put the wrong month 2.11 and did the test on 15.11

Hello dear Natalia.
In order not to torment yourself with doubts, hand over a blood test for hCG tomorrow (11/16/2015). Positive - keep supporting. Negative - cancel.
Good luck!

Post date: 15.11.2015 14:40

Elena

Good afternoon, Gary Zelimkhanovich !! Can you please tell me, after the embryo transfer, the doctor prescribed rotted 1500 to 0-4-8-11 in support (the transfer was on November 2, the first injection was on the same day at 21:00, the rest of the injections were, respectively, on November 6; 11; 11; 11/13/2015 at 18 : 00). ... The hCG analysis is scheduled for the morning of 11/16/2015. Will it be reliable ?? Thank you.

Post date: 15.11.2015 17:35

Dostybegyan Gary Zelimkhanovich

Hello dear Elena.
I work in the clinic, which in 1992 was the third in Russia to receive an IVF pregnancy.
This is the IDK Medical Company (Samara, now the IDK Mother and Child).
We never prescribe hCG support to anyone, only progesterone.
And we know for sure that if a woman has passed hCG on day 14 and it is positive, that this is pregnancy.
If you take a blood test three days after your hCG injection, it will be positive. But it is unlikely to be reliable.

Post date: 16.11.2015 23:07

Ekaterina

Hello, Gary Zelimkhanovich! On 12 DPO and 15 days after the injection of hCG 10000, the result in the blood is hCG 3.15. Can you please tell me if it is worth retaking the analysis in a few days or there is no hope in this cycle anymore?

Post date: 17.11.2015 04:28

Dostybegyan Gary Zelimkhanovich

Hello dear Catherine.
Unfortunately, the likelihood of pregnancy is minimal, but it is worth retaking the analysis after 2 days and then everything will be clear for sure.

Post date: 19.11.2015 16:17

Evgeniya

Hello, Gary Zelimkhanovich! On November 12, they gave an injection of hCG 10,000 for ovulation, on November 14 they repeated, another 10,000, because. There was no ovulation, IUI was done before her. How long does it take for such an injection dose to disappear? Control testing was scheduled for 28.11.

Post date: 19.11.2015 18:47

Evgeniya

And one more question, always and everyone has implantation bleeding? If so, when to expect it, on what day after ovulation? Thanks in advance!

Post date: 19.11.2015 19:02

Dostybegyan Gary Zelimkhanovich

"Implant bleeding" is very rare.
10,000 hCG will leave the body in 7-8 days.
Pregnancy control was correctly prescribed after 14 days.
Respectfully yours, fertility specialist Dostybegyan Gary Zelimkhanovich

Post date: 23.11.2015 04:22

Evgeniya

Gary Zelimkhanovich! The poet's soul could not bear it and rushed to heaven. I did a test in the morning, with a sensitivity of 25, the cheapest. A barely noticeable second stripe appeared, but noticeable. Is it still 10,000 hCG weathered, made on 11/14/15?

Post date: 23.11.2015 14:37

Dostybegyan Gary Zelimkhanovich

Hello dear Evgenia.
HCG, taken 9 days ago, left your body long ago and completely.
If after 2 days the test is brighter, you can be congratulated on your pregnancy.

WITH Best wishes, Dostybegyan Gary Zelimkhanovich, reproductive physician

Post date: 23.11.2015 14:50

Evgeniya

THANK YOU!!!

Post date: 23.11.2015 18:35

Post date: 28.11.2015 10:35

Ekaterina

Good afternoon, Gary Zelikhmanovich! On 11/12, I gave an injection of chorionic gonadotropin 10000, on 11/21, I made an ultrasound of the corpus luteum measuring 26/25 mm, the analysis of hCG on 21.11 showed 6.02. can you please tell me this hCG from the injection gives such indications or is possible pregnancy? thanks in advance!

Post date: 28.11.2015 22:17

Dostybegyan Gary Zelimkhanovich

Hello dear Catherine
1. The level of hCG is too low to talk about pregnancy.
2. It's definitely not after the injection, a lot of time has passed.
3. You need to retake hCG, you passed it too early, the date of hCG is 24, not 21, today, let me remind you, is 28 November. The rapid growth of hCG will indicate pregnancy.

Best wishes, Dostybegyan Gary Zelimkhanovich, reproductive physician

In vitro fertilization is the most effective method infertility treatment at the present time, but even he does not guarantee the onset of pregnancy from the very first protocol. To increase the likelihood of a successful outcome of the procedure, it is necessary to undergo examination and proper hormonal preparation.

To stimulate the ovaries and prepare the woman's body for embryo transfer, the reproductive physician may prescribe an appointment hormonal agents... One of the drugs that is necessary after the transfer to maintain pregnancy is Pregnyl. Let's consider how the drug works and how to use it.

Pregnyl is a drug of the group of gonadotropins, in particular hCG. Chorionic gonadotropin is a hormone that is found in small quantities in the body of men and women. Its concentration in the body increases greatly during the onset of pregnancy, in particular after implantation of the fetus.

Produces the hCG hormone in the natural cycle of the placenta. It is necessary to maintain the function of the ovaries, in particular the corpus luteum. The corpus luteum is a temporary gland that is responsible for the production of progesterone. And progesterone, in turn, relieves the spasm from the uterus and forces the body to accept the pregnancy. Thus, hCG in the right amount is necessary in order to maintain pregnancy and ensure normal nutrition for the fetus.

In the IVF protocol, embryo implantation occurs at a moment unexpected for the body, because the fertilization stage took place not in the fallopian tube, but in the incubator. This is not typical for the body, so progesterone becomes less than needed, and the corpus luteum may stop functioning prematurely and a miscarriage will occur.

To avoid this, it is necessary to support the pregnancy after the embryo transfer; progesterone and hCG injections are perfect for this.

An injection of Pregnil can also be prescribed before the puncture, this is necessary in order for the follicles to mature on time. The hCG hormone in the natural cycle provokes follicle rupture and ovulation.

Application

Injections of the Pregnyl preparation for IVF are given subcutaneously in the abdomen. It is quite simple to perform such injections, so the patient can inject herself at home. Dosage required in specific case, the reproductologist selects.

To prepare the ovaries for puncture, Pregnil is injected only once at a dosage of up to 10 thousand IU. Within 36 hours after the injection, a puncture must be done, otherwise ovulation will occur and cells will no longer be obtained. To maintain the work of the corpus luteum, two or three injections are prescribed in a small dosage of up to 3 thousand IU.

It is important to note that the use of Pregnyl after the transfer can provoke a false-positive pregnancy test or hCG test within 10 days after the last injection. Therefore, it is necessary to diagnose pregnancy only after this period.

Unfortunately, more and more modern women are faced with difficulties in conceiving a child. The desired pregnancy may, one of which may be a lack of female sex hormones - estrogen and progesterone, due to which the egg does not mature and ovulation does not occur. In this case, a woman at the planning stage of pregnancy (as well as to preserve it during gestation), together with supportive therapy, may be prescribed hormonal drugs, for example, Pregnyl.

What is Pregnyl?

Pregnyl is a preparation of the human chorionic gonadotropin hormone. It can be assigned to both women and men, and even children, but with completely different purposes. Most often, Pregnyl for women is prescribed when planning a pregnancy as an auxiliary method before, to stimulate the ovaries or to support the luteal phase of the menstrual cycle.

The course of treatment and dosages are determined by the doctor in each case individually.

Pregnyl is injected intramuscularly. Depending on the indications, the hormone can be administered once or several times at intervals of several days.

How long does Pregnil take off?

The maximum concentration of the hormone hCG in the blood plasma after the injection of Pregnil in women occurs after about 20 hours. The excess of the drug is excreted in the urine for several days after the injection. The elimination period of Pregnil depends on the dose: the larger it is, the longer it is. An earlier pregnancy test after Pregnil may show.

When can a pregnancy test be done after Pregnil?

Of course, every woman is eager to find out the result of this cycle and quickly find out if the long-awaited pregnancy has come. If you conduct a pregnancy test after Pregnil, then it should be borne in mind that, according to the instructions for the drug, it can be considered reliable when it is carried out on the 10th day and later after receiving the last injection of Pregnil. However, doctors recommend that the test be carried out no earlier than 2 weeks after ovulation or embryo replanting.

It should be noted that an early pregnancy test can be both false positive and false negative! So no premature conclusions, girls!

For reliability, it is necessary to monitor the level of hCG over time. It is best with a laboratory blood test, but at a later date after ovulation, several pregnancy tests can be done at intervals of several days.

The final "diagnosis" can only be made by a doctor. No rest in peace to you!

Especially for Elena Kichak

In this article, you can read the instructions for the use of the medicinal product. Pregnil... The reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Pregnil in their practice are presented. A big request is to actively add your reviews about the drug: did the medicine help or did not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Pregnyl's analogs if there are structural analogs available. Use for the treatment of infertility, stimulation of ovulation with IVF, maintenance of the corpus luteum phase in adults, children, as well as during pregnancy and lactation.

Pregnil- contains hCG (human chorionic gonadotropin). This hormone has a biological activity similar to that of LH (luteinizing hormone). LH is indispensable for the normal growth and maturation of female and male gametes and for the formation of sex hormones.

Among women:

• Pregnyl is used as a mid-cycle substitute for endogenous LH to induce the final phase of follicular maturation leading to ovulation. Pregnyl is also used as a substitute for endogenous LH during the luteal phase.

In men and boys:

• Pregnyl is used to stimulate Leydig cells to accelerate the formation of testosterone.

Compound

Human chorionic gonadotropin + excipients.

Pharmacokinetics

The maximum concentration of hCG in blood plasma after a single intramuscular or subcutaneous injection of hCG is achieved after 6-16 hours in men and approximately 20 hours in women. Despite the fact that there is a high individual variability, sex differences in the rate of absorption of the drug after a single IM injection are most likely associated with a greater thickness of subcutaneous fat in women. Approximately 80% of hCG is metabolized in the kidneys. It has been found that a single intramuscular or subcutaneous injection of hCG is bioequivalent in terms of the duration of absorption and an apparent half-life of approximately 33 hours. Given the recommended dosage regimens and half-life, cumulation of the drug is not expected.

Indications

Among women:

• induction of ovulation in infertility due to anovulation or impaired follicular maturation;
• preparation of follicles for puncture in programs of controlled ovarian hyperstimulation (for assisted reproduction techniques);
• maintaining the phase of the corpus luteum.

In boys and men:

• hypogonadotropic hypogonadism;
• delayed puberty due to insufficiency of the gonadotropic function of the pituitary gland;
• cryptorchidism not due to anatomical obstruction.

Forms of issue

Lyophilisate for the preparation of a solution for intramuscular and subcutaneous administration (injections in ampoules for injection) 500 IU, 1500 IU, 5000 IU and 10000 IU.

Instructions for use and scheme of use

After adding the solvent to the lyophilisate, the reconstituted Pregnyl solution is slowly injected intramuscularly or subcutaneously.

Among women:

• in case of ovulation induction in infertility due to anovulation or impaired follicular maturation, one injection of Pregnyl is usually performed at a dose of 5000 to 10000 IU to complete treatment with follicle-stimulating hormone (FSH) drugs;
• when preparing follicles for puncture in programs of controlled ovarian hyperstimulation;
• to maintain the corpus luteum phase, two to three repeated injections of the drug can be made at a dose of 1000 to 3000 IU each within 9 days after ovulation or embryo transfer (for example, on days 3, 6 and 9 after ovulation induction).

In boys and men:

• with hypogonadotropic hypogonadism: 1000-2000 IU of the drug Pregnyl 2-3 times a week. In case of infertility, it is possible to combine the drug Pregnyl with an additional drug containing follitropin (FSH) 2-3 times a week. The course of treatment should be continued for at least 3 months when any improvement in spermatogenesis can be expected. During this treatment, testosterone replacement therapy must be suspended. When an improvement in spermatogenesis is achieved, it is sufficient to maintain it, in some cases, the isolated use of hCG;
• with delayed puberty due to insufficiency of the gonadotropic function of the pituitary gland 1500 ME 2-3 times a week. The course of treatment is at least 6 months;
• with cryptorchidism, not due to anatomical obstruction;
• at the age of 2 years: 250 IU is administered twice a week for 6 weeks;
• at the age of 6 years: 500-1000 IU is administered twice a week for 6 weeks;
• over the age of 6: 1500 IU is administered twice a week for 6 weeks.

The course of treatment can be repeated if necessary.

Side effect

• generalized rash or fever;
• bruising, pain, redness, swelling, and itching at the injection site;
• pain and / or rash at the injection site;
• thromboembolism;
• hydrothorax;
• abdominal pain;
• nausea;
• diarrhea;
• ascites;
• unwanted ovarian hyperstimulation;
• moderate or severe OHSS;
• soreness of the mammary glands;
• slight to moderate enlargement of the ovaries and ovarian cysts associated with moderate OHSS;
• Large ovarian cysts (prone to rupture), usually associated with severe OHSS
• weight gain as a sign of severe OHSS;
• gynecomastia.

Contraindications

• hypersensitivity to human gonadotropins or to any component of the drug;
• established or suspected tumors dependent on sex hormones (ovarian cancer, breast and uterine cancer in women and prostate cancer, breast cancer in men).

Boys (optional):

• premature puberty;

In women (optional):

• malformation of the genitals, incompatible with pregnancy;
• fibrous tumor of the uterus, incompatible with pregnancy.

Application during pregnancy and lactation

Application during pregnancy, during lactation is contraindicated.

Pregnyl can be used to maintain the function of the corpus luteum of the ovary, but should not be used during pregnancy. Pregnyl should not be used during lactation.

Application in children

Can be used in children according to indications.

Contraindicated in boys with premature puberty.

special instructions

In men and boys, treatment with hCG leads to an increase in androgen production.

• patients with latent or overt heart failure, impaired renal function, arterial hypertension, epilepsy or migraine (or with a history of these conditions) should be under strict medical supervision, since an exacerbation of the disease or relapse can sometimes be the result of increased production of androgens;
• HCG should be used with caution in prepubertal boys to avoid premature epiphyseal closure or premature puberty. The development of the skeleton should be monitored regularly.

Among women:

• in pregnancy that has arisen after the induction of ovulation with gonadotropic drugs, there is an increased risk of multiple pregnancy;
• Since infertile women undergoing assisted reproductive technologies, and especially in vitro fertilization, often have fallopian tube abnormalities, the incidence of ectopic pregnancies may increase. Therefore, early ultrasound confirmation that the pregnancy is intrauterine is important;
• the frequency of pregnancy loss in women undergoing assisted reproductive technologies is higher than in the general population;
• the presence of uncontrolled extragonadal endocrinopathies (for example, diseases of the thyroid gland, adrenal glands, or pituitary gland) should be excluded;
• the incidence of congenital malformations after assisted reproductive technologies (ART) may be slightly higher than as a result of spontaneous conception. It is believed that this slightly increased frequency is associated with the characteristics of the parents (maternal age, sperm characteristics), as well as with the high frequency of multiple pregnancies after ART. There is no indication that an increased risk of congenital malformations is associated with the use of gonadotropins during ART;
• unwanted ovarian hyperstimulation:

in patients receiving combined FSH / hCG therapy for infertility due to anovulation or impaired follicular maturation, the use of an FSH-containing drug may lead to unwanted ovarian hyperstimulation. Therefore, before starting FSH treatment and at regular intervals during FSH treatment, ultrasonography should be performed to assess follicular development and to determine estradiol levels. Estradiol levels can rise very rapidly, for example, over two or three consecutive days, there can be more than a daily doubling, and can reach extremely high values. The diagnosis of unwanted ovarian hyperstimulation can be confirmed by ultrasound. In the event of unwanted ovarian hyperstimulation (i.e., not as part of a treatment aimed at preparing for in vitro fertilization with embryo transfer (IVF / PE), intratubal gamete transfer (GIFT), or intraplasmic sperm injection (ICSI)), administration of FSH-containing the drug must be discontinued immediately. In this case, it is necessary to avoid pregnancy and not to inject the drug Pregnyl, since the administration of LH-active gonadotropin at this stage can cause, in addition to multiple ovulation, OHSS. This warning is especially important in patients with polycystic ovaries. Clinical symptoms of moderate OHSS are gastrointestinal disturbances (pain, nausea, diarrhea), breast tenderness, and mild to moderate enlargement of the ovaries and ovarian cysts. There have been reports of transient abnormalities in liver function tests associated with OHSS, indicative of hepatic dysfunction, which may be accompanied by morphological changes on liver biopsy.

In rare cases, severe OHSS occurs, which can be life threatening. It is characterized by large ovarian cysts (prone to rupture), ascites, mass gain, often hydrothorax, and in some cases, thromboembolism.

Pregnyl should not be used to reduce body weight. HCG has no effect on fat metabolism, fat distribution, or appetite.

Influence on the ability to drive vehicles and use mechanisms

According to available data, the drug does not affect the speed of psychomotor reactions and concentration.

Drug interactions

Since the interaction of the drug Pregnyl with other drugs has not been studied, such an interaction cannot be ruled out.

During treatment with Pregnyl and within 10 days after stopping treatment, it can affect the values ​​of immunological tests for the content of hCG in serum / urine, which can lead to a false positive pregnancy test result.

Analogs of the drug Pregnil

Structural analogues for the active substance:

• Chorionic gonadotropin for injection;
• Profazi;
• Horagon;
• Ecotimulin.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.

Hello everyone.

My path to pregnancy was not the easiest one. Stress, crazy hormones, lack of periods, stimulation of ovulation. And it was on stimulation that I needed to inject hCG - so that the mature follicles did not turn into a cyst.

Pregnyl - Pharmacological action

Pregnyl® contains human chorionic gonadotropin (hCG). This hormone has a biological activity similar to that of luteinizing hormone (LH). LH is indispensable for the normal growth and maturation of female and male gametes and for the formation of sex hormones.

In women: Pregnyl® is used as a mid-cycle substitute for endogenous LH to induce the final phase of follicular maturation leading to ovulation. Pregnyl® is also used as a substitute for endogenous LH during the luteal phase.

As I already wrote, at the moment the injection was given to me in two cycles of ovulation induction - the first was on Klostilbegit, the second - on Femara letrozole.

Stimulation with clostilbegit was rather a trial one, since the ovaries did not react to our domestic letrozole, so heavy artillery was used. The follicle has matured, which means that everything is not so bad.

Then 5000 IU was injected and ovulation occurred, but pregnancy did not occur. Perhaps the endometrium has not grown enough (this is Klost's trouble), perhaps some other factor worked (there could be a defective egg, since the injection is usually done at a smaller size, we did not think that it would grow so quickly), but we switched again to letrozole, but already Femara.

Pregnyl - Pharmacokinetics

The maximum concentration of hCG in blood plasma after a single intramuscular or subcutaneous injection of hCG is achieved, respectively, after 6 and 16 hours in men and women and, in both cases, after about 20 hours. Despite the fact that there is a high individual variability, sex differences in the rate of absorption of the drug after a single intramuscular injection are associated, rather, with a greater thickness of subcutaneous fat in women. Approximately 80% of hCG is metabolized in the kidneys. A single intramuscular or subcutaneous injection of hCG has been found to be bioequivalent in terms of duration of absorption and an apparent half-life of approximately 33 hours. Given the recommended dosage regimens and elimination half-life, cumulation of the drug is not expected.

This time, 3 follicles have matured. The doctor warned about the risk (it sounded cool, not an opportunity, but a risk) of multiple variability, since all 3 follicles can ovulate, respectively, 3 eggs can be fertilized.

It was only necessary to help them do it - and again an injection of hCG. This time they decided to inject 10,000 IU.

Release form

Lyophilisate for the preparation of a solution for intramuscular and subcutaneous administration of 1500 and 5000 IU complete with a solvent (sodium chloride solution 0.9%).

5000 IU of lyophilisate in a type I (EF) colorless glass ampoule with a capacity of 2 ml. On the top of the ampoule there is a yellow ring and a black dot under it.

1 ampoule of 5000 IU of lyophilisate, complete with 1 ampoule of solvent, each ampoule is fixed with two fixators, placed in a cardboard box along with instructions for use.

I bought two packs of 5,000 IU of Pregnil and decided to make an injection in each bun. My husband's hand was trembling. He gives himself injections for one or two, he is afraid of hurting me. Here he is so caring for me.

Pregnyl - Contraindications

Hypersensitivity to human gonadotropins or to any component of the drug;

Established or suspected tumors that are sex hormone dependent (ovarian cancer, breast cancer and uterine cancer in women, and prostate cancer, breast cancer in men).

Abnormal formation of the genitals, incompatible with pregnancy;

Fibrous tumor of the uterus, incompatible with pregnancy.

Pregnyl - Interaction with other medicinal products

Since the interaction of Pregnil® with other drugs has not been studied, such an interaction cannot be ruled out.

Within 10 days after stopping treatment with Pregnil®, it may affect the values ​​of immunological tests, the content of hCG in serum / urine, which can lead to a false positive pregnancy test result.

Actually, ovulation occurred and the doctor saw 3 corpus luteum on the ultrasound at once. Of course, she reminded about multiple pregnancy but it's late what's done is done

HCG injection not the most pleasant, but you can endure. By the way, they are dispensed by prescription, and this is good, because at least you can buy rotten and you can in every pharmacy, but without consulting a doctor, it is dangerous to carry out such treatment and no matter how much I know on this topic, I visited a gynecologist and reproductologist.

Hormonal drugs are not cheap, he was no exception and rotted - the price for it fluctuates between $ 13-16 for 5000 IU. There are also analogues - in this case, rot is not the only drug and you can choose something from this list - Hogagon, Choriomon, Ovitrel, Ovitrel, Elonva - depending on which drug is sold in your country.